High s creatinine levels12/28/2022 Typically, GFR must be reduced by ~50 % before plasma urea or creatinine concentration rise above the upper limits of their respective reference range. it is only affected by change in GFR)īoth plasma urea and plasma creatinine concentration are imperfect indices of GFR neither analyte entirely fulfills the above criteria (see Table I below) and both lack sensitivity to detect minimal change in GFR.
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